Nhà Bè's history is a story of a river crossing that grew into a trading post, then a district, then — repeatedly — gave away pieces of itself to its neighbors.
Nguyễn Hữu Cảnh formally establishes Gia Định prefecture on behalf of the Nguyễn lords; the hamlets that will become Nhà Bè fall under Tân Bình district, Phiên Trấn dinh, from this point forward.
As Nguyễn-era land clearance intensifies across the region, the name "Nhà Bè" begins to circulate — see Anecdotes, below, for the story behind it.
French colonial authorities formally place the name on the map, dividing Gia Định province into four districts: Hóc Môn, Thủ Đức, Gò Vấp and Nhà Bè. At this stage Nhà Bè district is large, comprising four cantons — Bình Trị Hạ, Dương Hòa Hạ, An Thít and Cần Giờ — stretching along the boundary between the Nhà Bè and Lòng Tàu rivers.
The An Thít and Cần Giờ cantons are separated from Nhà Bè district and folded into Vũng Tàu province, leaving Nhà Bè with just the Bình Trị Hạ and Dương Hòa Hạ cantons — roughly the district's territory as it existed before 1975.
Nhà Bè becomes a district of Ho Chi Minh City following reunification.
Nhà Bè township, the district's administrative seat, is formally established from land cut out of Phú Mỹ and Phú Xuân communes.
Several communes are cut from Nhà Bè district to help form the newly created District 7 — the second time in the district's history that it has given up territory to a neighboring administrative unit, echoing the 1947 loss of An Thít and Cần Giờ.
A citywide ward reform merges Nhà Bè township with the communes of Phú Xuân, Phước Kiển and Phước Lộc into a single new commune named Nhà Bè, part of a broader restructuring across Ho Chi Minh City.